Random Number Generation, or RNG, is a highly debated topic in almost every competitive video game genre.

However, it still exists in subtle ways that can completely alter the outcome of a very close match.
Starting Hands and Card Rotation
Your starting hand is entirely random, which can immediately put you at a massive disadvantage against an aggressive opening.

By ensuring a healthy mix of low-cost cycle cards, they guarantee they will always have some form of defense.
Always include at least two cheap defensive options.Cycle your cheapest cards in the back.It happens to everyone. Unit Targeting and Pathfinding
Sometimes a unit will retarget unexpectedly due to a micro-movement by another troop, completely ruining your defensive setup.

Relying on a unit's aggro range down to the exact pixel is risky because tiny bumps can alter their trajectory.
Game StyleRandomness ImpactDrafting GamesLuck is the primary factor in individual matchesStandard Tower RushHighly skill-dependent after the first 30 seconds Embracing the Chaos
The best competitors accept the chaos, focus on what they can control, and outplay the opponent regardless.

Over the course of a thousand games, the luck factor completely evens out for everyone.